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a. Rice researchers have developed a ruthenium-based complex able to track the formation of soluble amyloid beta peptide aggregates implicated in the onset of Alzheimer’s disease. Photo by Jeff Fitlow b. A ruthenium-based tag developed at Rice takes advantage of fluorescent anisotropy to measure the rotation of amyloid beta oligomers as they grow in solution. Small aggregates rotate fast, while large oligomers rotate slowly, a characteristic that lets researchers watch as they grow. Amyloid beta oligomers are toxic to neurons and implicated as a possible cause of Alzheimer’s disease. Courtesy of the Angel Martí Group

Shedding new light on Alzheimer’s cause

Rice scientists synthesize fluorescent ruthenium tags to track toxic amyloids in lab.
Microglia, shown in red, surround and react to the amyloid-beta plaques, shown in green, in the Alzheimer's disease brain. CREDIT Kim Green lab / UCI

Scientists identified the link between brain immune cells and Alzheimer’s disease development

UCI study finds the absence of microglia prevents plaque formation.
Alzheimer's disease destroys neurons that keep us awake

Alzheimer’s disease destroys neurons that keep us awake

A study suggests Tau tangles, not amyloid plaques, drive daytime napping that precedes dementia.
Neurons in the hippocampus, a brain region for learning and memory, that is impaired already at early stages of Alzheimer´s disease. Image: Y. Zhang und A. Konnerth / TUM

Direct toxic action of beta-amyloid identified

Scientists have identified early cellular dysfunction in Alzheimer's patients who have already developed clinical symptoms contain large clumps of the protein beta-amyloid, known as plaques.
A new blood test for early detection of Alzheimer’s disease

A new blood test for early detection of Alzheimer’s disease

Alzheimer's is the most common cause of dementia that causes problems with memory, thinking, and behavior. The disease accounts for 60% to 80% of...
Blood pressure device

Common blood pressure pill could slow down Alzheimer’s

While searching for the treatments that slow down the progression of Alzheimer's, scientists discovered that the common blood pressure drug nilvadipine might hold the...
brain

Biggest ever map of human Alzheimer’s brain published

Scientists at the The University of Manchester have created the largest ever dataset of differences between healthy brains and those with Alzheimer’s Disease. Moreover, scientists also...
Image of P. gingivalis' gingipains in the neurons of Alzheimer's brain. P. gingivalis gingipains = red, neurons = yellow, astrocytes = green. Credit: Cortexyme, Inc.

Scientists may finally know what causes Alzheimer’s

A team of international scientists led by Cortexyme, Inc., a privately held, the clinical-stage pharmaceutical company has recently discovered the role of a common bacterium, Porphyromonas...
Antipalaptic drugs are associated with accumulation of hospital days in people with Alzheimer's disease

Antipalaptic drugs are associated with accumulation of hospital days in people with Alzheimer’s disease

Antiepileptic drugs (AEDs) are as often used among more seasoned people and particularly among those with Alzheimer's disease. Although the essential sign for AED...

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