Home Health Children with dengue infection could be protected from symptomatic Zika

Children with dengue infection could be protected from symptomatic Zika

Children with a prior dengue infection were 38 percent less likely to develop symptomatic Zika than children without prior dengue exposure.

Dengue has been endemic to the Americas, Zika wasn’t reported in the region until 2015. The viruses are very similar: they are transmitted by the Aedes aegypti mosquitoes and can cause similar symptoms, including fever, rash, and joint and muscle pain.

Those who work on mosquito-borne diseases believe there is an immunological interaction between dengue and Zika.

A new study by the Michigan and California scientists suggests that prior dengue virus infection could protect children from symptomatic Zika virus infection. These findings support the idea that prior dengue infection might cross-protect against symptomatic Zika.

Study lead author Aubree Gordon said, “We don’t think that that dengue immunity protects from being infected (with Zika), or at least it doesn’t look like that is the case in our study. However, for children who were infected with Zika, prior dengue exposure protected them from symptomatic Zika disease.”

Study team member Ingrid Massiel Mercado processes a blood sample in a neighborhood in Managua in June 2017 as part of the Nicaraguan Pediatric Dengue Cohort Study (PDCS), a long-standing pediatric dengue cohort established in 2004. Image credit: Sustainable Sciences Institute, Paolo Harris Paz.
Study team member Ingrid Massiel Mercado processes a blood sample in a neighborhood in Managua in June 2017 as part of the Nicaraguan Pediatric Dengue Cohort Study (PDCS), a long-standing pediatric dengue cohort established in 2004. Image credit: Sustainable Sciences Institute, Paolo Harris Paz.

For their study, scientists gathered the data from their long-standing Pediatric Dengue Cohort Study, established in 2004 in Managua.

Of the roughly 3,700 participants (children ages 2-14), 3,027 had known dengue infection histories, with 743 of them having at least one prior dengue infection and 176 with recent dengue infection. Through testing, researchers found that 1,356 of them had had a Zika infection, and of those, 560 had symptomatic Zika.

Scientists then contrasted the children with prior dengue infection to those who had not to know whether prior dengue infection affected whether the children were infected with Zika and the severity of the infection.

Scientists found that children with a prior dengue infection were 38 percent less likely to develop symptomatic Zika than children without prior dengue exposure.

Study co-author Eva Harris said, “Researchers are paying special attention to a phenomenon called ‘antibody-dependent enhancement. In some cases, people who had a previous dengue infection develop antibodies that, instead of protecting their hosts, making them unable to fight a subsequent infection, enhancing it instead.”

“However, in the current study, we did not examine severe Zika outcomes. We analyzed uncomplicated Zika in our pediatric population and found that prior dengue infection actually protected against the disease. This is consistent with our previous studies on the role of dengue antibodies in relation to uncomplicated dengue disease.”

Study personnel prepare to collect blood samples from children in a neighborhood in Managua in June 2017 as part of the Nicaraguan Pediatric Dengue Cohort Study (PDCS), a long-standing pediatric dengue cohort established in 2004. Image credit: Sustainable Sciences Institute, Paolo Harris Paz.
Study personnel prepare to collect blood samples from children in a neighborhood in Managua in June 2017 as part of the Nicaraguan Pediatric Dengue Cohort Study (PDCS), a long-standing pediatric dengue cohort established in 2004. Image credit: Sustainable Sciences Institute, Paolo Harris Paz.

Gordon said, “If there are interactions if it protects you from dengue, that’s great. Or if it helps protect you from being symptomatic, fine. But there is always the concern that the antibodies are protective to a certain point, and once they reach a certain level they are now a risk for severe disease. And so I think that needs to be looked at pretty closely.”

The study, published in PLOS Medicine, was supported by grants R01 AI099631 (AB), P01 AI106695 (EH) and U19 AI118610 (EH) from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, as well as grant VE-1 (EH) from the Pediatric Dengue Vaccine Initiative of the Bill and Melinda Gates Foundation.

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