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Schematic of the setup for photo-thermal induced resonance (PTIR), which includes an infrared laser source and atomic force microscope (AFM) cantilever with a sharp tip that touches the sample and vibrates in response to the sample’s light-induced expansion. PTIR can determine the folding pattern (called for example α-helix, β-sheet) of peptides (amino acid chains) in water with nanometer-scale resolution. Credit: NIST

First nanometer-scale measurements of the folded structure of biomolecules in liquids

Scientists have previously developed a spectroscopy technique to measure a material's topography and chemical composition with nanometer-scale. Now NIST scientists came up with little improvement...