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In this structural model for a beta-lactamase protein, catalytic residues are shown as spheres with those that are consistently highly frustrated along the entire beta-lactamase family shown in red and those for which the frustrated state is not conserved in yellow. The new work by scientists at Rice University, the University of Buenos Aires and the European Molecular Biology Laboratory suggests these enzymes, which must remain exposed to react with their targets, get a measure of protection from the somewhat-frustrated amino acids around them. The green lines represent minimal frustration, the red lines represent high frustration. The linear charts at top and bottom show the positions of the relevant amino acids on the protein chain and a measure of the conservation of energy over the entire beta-lactamases protein family. Illustration by Maria Feiberger

Working proteins make good use of frustration

Proteins- active sites of enzymes- accelerates and guide biochemical reactions make life possible. To do this, their instructions have to conflict somewhat with the...
blood cells, cells interaction

New method identifies how drugs attack bad cells

A team of scientists at the Ben-Gurion University of the Negev has demonstrated a new method to target specific proteins, protein family and especially protein-to-protein...
(Illustration by Michael S. Helfenbein)

Scientists found a new way to create designer human proteins

Proteins are essential for life functions. Most human proteins are changed by a procedure called serine phosphorylation. Glitches in this procedure have been embroiled in...
healthy eating and diet concept - natural rich in protein food on table

High protein diet slightly increases heart failure risk in middle-aged men

A new study by the University of Eastern Finland suggests that intaking higher amounts of protein was associated with a slightly elevated risk for heart failure...
Treatment that Destroy Cancer Cells by Themselves

Treatment that Destroy Cancer Cells by Themselves

Cancer cells can grow any place in the body and crowds out normal cells. This causes problems in the part of the body where cancer started....
Computer Model to Control Proteins at a Long Distance

Computer Model to Control Proteins at a Long Distance

Proteins are involved in every biological process. It increases the rate of virtually all the chemical reactions within cells. Because of its fundamental properties, drug...
New Way to Create Synthetic Proteins

A New Way to Create Synthetic Proteins Could Lead to more Flexible Designs

As we know, proteins play a various role in our body. They have created useful and essential biological materials. For example, spider silk, which...

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