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A molecular model for regulating Rad51 nucleoprotein filament formation by the Swi5-Sfr1 complex. Swi5–Sfr1 stabilizes Rad51 on ssDNA primarily by preventing its dissociation. This stabilization effect leads to a stable nucleating cluster formation and a reduction in filament disassembly. Red half-arrows indicate the kinetic steps affected by SSwi5–Sfr1.

Scientists unraveling the molecular details of DNA recombination regulation

A worldwide group from National Taiwan University (NTU) and Tokyo Tech distinguished how DNA recombinational repair is directed in an ongoing work distributed in...