Single-cell ‘computers’ aid instruct learned behavior

Two plasticity mechanisms act within a single neuron to express a memory in the worm C. elegans.


The nervous system has the ability to change in view of involvement. This versatility is thought to support the development and recovery of recollections. How the pliancy of individual neurons adds to learned behavior is a basic and unanswered in neuroscience. Now, Yale researchers demonstrate that two pliancy instruments act inside a solitary neuron to express memory in the worm C. elegans.

C. elegans can be prepared to lean toward a temperature, and the scientists, driven by neuroscientists Daniel Colón-Ramos and Josh Hawk, examined what occurs at the cell level when creatures figure out how to favor another temperature. They found that a tangible neuron in the worm can coordinate two pliancy instruments to manage learned behavior inclinations.

Sensory adaption enables the neuron to go about as a kind of compass, telling the worm which way it is bearing at a temperature angle. Presynaptic pliancy goes about as a ‘data entryway’ that, in light of scholarly conduct, administers whether temperature data is handed off to different neurons or not, subsequently controlling its development. Together, these instruments make a solitary cell rationale framework that clarifies how the creature, the two, detects temperature and reacts to it in view of a past memory.

Colón-Ramos noted, “Our work shows that each individual neuron is capable of acting as a computer, integrating plasticity mechanisms to process information that initiate complex behaviors.”

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