New Hydrogel Hybrid doesn’t Dry Out

The water-based material could be used to make artificial skin, longer-lasting contact lenses.

New Hydrogel Hybrid doesn’t Dry Out
Engineers at MIT have devised a method to bind two stretchy materials: gelatin-like polymer materials called hydrogels, and elastomers, which are impervious to water and can thus seal in the hydrogel’s water. Photo: Melanie Gonick/MIT

If we put a cube of Jell-O on the counter of the kitchen, ultimately the water inside it will start evaporating. It leaves a dry, hardened mass known as jelly. The similar is for hydrogels too. The hydrogel is a gel in which the liquid component is water. It consists of a large amount of water and is stretchy and absorbent until they inevitably dry out.

Recently, engineers at MIT have cultivated a new way to protect hydrogels from dehydrating. This new technique can be used in longer-lasting contact lenses, flexible bioelectronics, and even in artificial skin.

The team of researchers formulates a method for powerfully tighten hydrogels to elastomers. Elastomers are elastic polymers such as rubber and silicone that are stretchy like hydrogels yet impervious to water. They found that by coating hydrogels with a thin elastomer layer gives a water-trapping obstruction that kept the hydrogel wettish, flexible, and strong.

This research is lead under the guidance of Xuanhe Zhao, the Robert N. Noyce Career Development Associate Professor in MIT’s Department of Mechanical Engineering.

New Hydrogel Hybrid doesn’t Dry Out
Figure (a) shows the fabrication procedure for a hydrogel-elastomer microfluidic chip. Figure (b) shows that the hydrogel-elastomer microfluidic hybrid supports convection of chemicals (represented by food dye in different colors) in the microfluidic channels and diffusion of chemicals in the hydrogel, even when the material is stretched, as seen in figure (c). In figure (d), the microfluidic hybrid is used as a platform for a diffusion-reaction study. Acid and base solutions from two microfluidic channels diffuse in the pH-sensitive hydrogel and form regions of different colors (light red for acid and dark violet for base).
Courtesy of the researchers

He said, “We got inspiration for its design from human skin, which is composed of an outer epidermis layer bonded to an internal dermis layer. The epidermis acts as a shield. It protects the dermis and its network of nerves and capillaries, as well as whole body’s muscles and organs, from drying out.”

The team’s hydrogel-elastomer hybrid is similar to, and also stronger than, the bond between the epidermis and dermis. The team has developed a physical model to determine the design of different hydrogel-elastomer bonds. Additionally, the team finding various applications for this hybrid material, including artificial skin. The results are published today in the journal Nature Communications. In the same paper, they also have reported inventing a technique to draw tiny channels into the hybrid material, similar to blood vessels. They have fixed complex ionic circuits in the material to perform nerve networks.

Zhao says, “We hope this work will pave the way to the synthetic skin, or even robots with very soft, flexible skin with biological functions.”

Procuring inside skin:

In December 2015, Zhao’s team developed a technique to get extremely strong bonding of hydrogels to solid surfaces such as metal, ceramic, and glass. The researchers used the technique to implant electronic sensors within hydrogels to create a smart bandage. They found, although, that the hydrogel would ultimately dry out by losing its flexibility.

Zhao said, “This method can make a hydrogel inappropriate with biological tissues, and even harmful. Rather than this, researchers got inspired by skin. Through this, they analyze that coating hydrogels with a material that was similarly stretchy. But it is also water-resistant would be a better strategy for preventing dehydration. They landed on elastomers as the ideal coating. Although this rubbery material had a major challenge: It was inherently resistant to bonding with hydrogels.

Yuk said, “Most elastomers are hydrophobic. It simply means they do not like water. But hydrogels are a modified version of water. So these materials don’t like each other much and usually, can’t form a good attachment.”

By using the technique developed for solid surfaces, the team tried to tighten the materials together. But with elastomers, the hydrogel bonding was extremely weak. After searching for a summary on chemical bonding agents, the researchers found a candidate compound that might bring hydrogels and elastomers together. The compound is known as benzophenone, which activated via ultraviolet (UV) light.

After submerging a thin elastomer sheet into a benzophenone solution, the researchers covered the submerged elastomer around a hydrogel sheet and reveals the hybrid to UV light. After 48 hours in a dry laboratory environment, the weight of the hybrid material did not change. Thus it indicates that the hydrogel kept most of its moisture. They also calculate the force needed for covering two materials separately and found that 1,000 joules per square meters are required to separate them. This much higher than the force needed to cover the skin’s epidermis from the dermis.

Zhao said, “This is tougher than skin. We can also stretch the material to seven times its original length, and the bond still holds.”

Extending the hydrogel toolset:

By comparing with skin, the team develops a technique to draw tiny channels within the hydrogel elastomer hybrid for pretending simple network of blood vessels. First, they heal a common elastomer onto a silicon wafer patterning with a simple three-channel pattern, etching the pattern onto the elastomer using soft lithography. After that, they immersed the patterned elastomer in benzophenone. It then produces a sheet of hydrogel over the elastomer and revealed all layers to ultraviolet light. During the test, the researchers were able to flow red, blue, and green food coloring through each channel in the hybrid material. This hybrid-elastomer material can be use as a rubbery microfluidic bandage for delivering drugs directly through the skin.

Yuk said, “We showed that we can use this as a stretchable microfluidic circuit. In the human body, things are moving, bending, and deforming. Here, we can perhaps do microfluidics and see how the device behaves in a moving part of the body.”

Scientists also investigate the hybrid material’s potential as a complex ionic circuit. This neural network is a circuit that irritates in the skin to send ions back and forth to signal sensations such as heat and pain. Generally, hydrogels consist of water and are natural conductor through which ions can flow. The addition of an elastomer layer, acts as an insulator, preventing ions from escaping. This is an important combination for any circuit.

To make it conductive to ions, the researchers dip this hybrid material in a condensed sodium chloride solution. After that, it connected to the material to an LED light. The scientists were then able to produce an ionic current that switched on the light by placing electrodes at the end of the material.

Yuk says, “We show very beautiful circuits not made of metal, but of hydrogels, simulating the function of neurons. We can stretch them, and they still maintain connectivity and function.”

The hydrogels and elastomers have different physical and chemical properties. When combined, it may cause new applications.

Yun, who was not involved in the research said, “It is a thought-provoking work. Among many applications, I can imagine smart artificial skins that are implanted and provide a window to communicate with the body for controlling health, sensing pathogens, and delivering drugs.”

The team is thinking to test this hybrid material’s potential in various applications. The applications might be are wearable electronics and on-demand drug-delivering bandages, as well as non-drying, circuit-embedded contact lenses.

Zhao said, “Ultimately, we’re trying to expand the argument of using hydrogels as an advanced engineering toolset.”