High-fat diet appear bad for blood pressure in younger males and females

About 1 in 3 adults in the United States is hypertensive, according to the Centers for Disease Control and Prevention, and about two-thirds of cases are associated with excessive weight gain.


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While diets high in foods rich in fat like meats, cheeses, butter, dairy, and egg yolks are popular, they don’t come without some consequences. A new study has also provided additional evidence that a high-fat diet is bad for both younger males and females.

The study hypothesized that high-fat fare would be harder on males, they found that in only a month both young male and female rats experienced practically identical increments in blood pressure.

Dr. Jennifer C. Sullivan, pharmacologist, and physiologist in the Department of Physiology at the Medical College of Georgia at Augusta University said, “You have a lot of people consuming high-fat diets and we don’t know enough about what effect it’s having on females.”

The study looked at youthful males and female Dahl salt-sensitive rats, bred to wind up hypertensive in light of a high-salt diet. More recently, male Dahl rats have been shown to also have significant blood pressure response to a high-fat diet.

The usual cardiovascular protection afforded to younger females appeared lost in the face of high-fat consumption. While the young male rats, like male humans, started out with higher blood pressure than their female counterparts, both sexes rapidly experienced a comparable degree of blood pressure increase.

In both genders, the high-fat diet additionally increased inflammation advancing T cells and diminished the quantity of irritation hosing administrative T cells, or Tregs, in the aorta, the greatest vein in the body which they considered for instance of what was going on inside veins.

However, that is the place some sex contrasts surfaced. Females ordinarily have a higher level of Tregs, which enable them to diminish blood pressure, and keeping in mind that both males and females encountered the decrease the females kept up that higher rate paying little mind to what they consumed. Different investigations have appeared because of things that could expand pulse, similar to high-salt or high-fat intake, females really increment the level of Tregs and maintain good pressure.

In the kidneys, which play a major role in regulating blood pressure, they again found increases in inflammation-promoting T cells in both sexes but a greater increase in males.

Sullivan reiterates that the changes – in males and females alike – were independent of a significant weight gain and occurred in just four weeks.

The high-fat diet actually decreased blood levels of triglycerides, a type of fat considered a risk factor for cardiovascular disease, in the males but increased it in females. Cholesterol and blood glucose levels were not really affected in either sex.

Scientists are now directly addressing the hypothesis that T cells contribute to blood pressure increases on a high-fat diet and whether that diet is directly driving an immune response that drives the blood pressure. She suspects it’s the changes to fat cells driving it rather than direct interaction between high-fat food and the immune response.

American Heart Association and the National Health and Nutrition Examination Survey noted, “The prevalence of metabolic syndrome – a cluster of cardiovascular risks that include higher blood pressure, blood sugar, and cholesterol levels and more fat particularly around the waist – is higher in females than males, 34.4 percent compared with 29 percent, respectively. Obesity rates are approaching 40 percent in adults and 20 percent in children, with female and minority populations more likely to be obese than male and white counterparts, the organizations report.”

The study is published in the American Journal of Physiology, Heart and Circulatory Physiology.


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