Cinnamon, a common holiday spice used mainly as an aromatic condiment and flavoring additive in a variety of cuisines, sweet and savory dishes. Now, according to a new study, it can be used to fight obesity also.
A previous study suggests that due to cinnamaldehyde, through which cinnamon has its flavor, seemed to secure mice against stoutness and hyperglycemia. But the mechanisms underlying the effect has not yet understood properly.
Thus, scientists at the University of Michigan take a step forward in order to properly understood cinnamaldehyde’s action and determine whether it might be protective in humans, too.
Scientists mainly wanted to discover how or what pathway might be involved, what it looked like in mice and what it looked like in human cells.
Scientists tested human adipocytes from volunteers representing a range of ages, ethnicities, and body mass indices. At the point when the cells were treated with cinnamaldehyde, the specialists saw expanded articulation of a few qualities and proteins that improve lipid digestion.
Later, they observed an increase in Ucp1 and Fgf21, which are important metabolic regulatory proteins involved in thermogenesis. They found that the cinnamaldehyde improves metabolic health by acting directly on fat cells, or adipocytes. It induces fat cells by burning energy through a process called thermogenesis.
Jun Wu, research assistant professor at the LSI said, “Cinnamon has been part of our diets for thousands of years, and people generally enjoy it. So if it can help protect against obesity, too, it may offer an approach to metabolic health that is easier for patients to adhere to.”
Adipocytes generally store vitality as lipids. This long-term storage was advantageous to our far-off precursors, who had substantially less access to high-fat nourishment and hence a considerably more noteworthy need to store fat. That fat could then be utilized by the body in the midst of shortage or in cool temperatures, which prompt adipocytes to change over put away vitality into warm.
Wu said, “It’s only been relatively recently that energy surplus has become a problem. Throughout evolution, the opposite energy deficiency has been the problem. So any energy-consuming process usually turns off the moment the body doesn’t need it.”
With the rising obesity epidemic, scientists are discovering ways to prompt fat cells to activate thermogenesis, turning those fat-burning processes back on.
According to Wu, cinnamaldehyde may offer one such activation method. As it is already in use in the food industry, it might be easier to convince patients to stick to a cinnamon-based treatment than to a traditional drug regimen.
Still, the further study required to determine how best to harness cinnamaldehyde metabolic benefits without causing adverse side effects.