Scientists at the The University of Manchester have created the largest ever dataset of differences between healthy brains and those with Alzheimer’s Disease. Moreover, scientists also discovered a region of the brain previously thought to be unaffected by the disease, the cerebellum, displayed a series of changes which they think might protect it from damage caused by Alzheimer’s.
The analysis, mapping the relative levels of over 5,825 distinct proteins across six regions of the brain, generated a massive 24,024 data points.
The brain regions in the study included the more heavily affected Hippocampus, Entorhinal cortex, Cingulate gyrus and the less affected Motor Cortex, Sensory Cortex, and Cerebellum
The samples were donated for research by patients at the New Zealand Brain Bank in Auckland.
Dr Richard Unwin at The University of Manchester said, “This database provides a huge opportunity for dementia researchers around the world to progress and to follow-up new areas of biology and develop new treatments. It could also help validate observations seen in animal or cell disease models in humans.”
“It’s very exciting to be able to make these data public so scientists can access and use this vital information.”
Scientists observed different parts of that pathway and identified how Alzheimer’s progresses in more detail.
Unwin said, “We think that the changes we see in the regions affected later on-represent early disease changes, present before cells die. These represent good new targets for drug developers, as we know it’s important to try to intervene early.”
In the course of the study, the team hit upon new molecules not previously associated with the disease, representing more targets to develop new drugs.
They also confirm that researchers looking at a range of pathways – including inflammation, Wnt signaling, and metabolic changes in human tissue – are on the right track.
The team identified 129 protein changes which were present in all areas of the brain studied, with at least 44 not previously associated with the disease.
He added: “These new protein changes represent further targets for scientists developing new drugs.”
“The cerebellum previously thought be unaffected, displays a significant response at the molecular level.”
“Many of the changes here are not seen in other regions and this could imply that this region actively protects itself from the disease. We won’t know for sure until we carry out more research.”
Dr Rosa Sancho, Head of Research at Alzheimer’s Research UK, said: “By studying thousands of individual proteins, this exciting research has generated a detailed molecular map of changes that get underway in the brain in Alzheimer’s disease. Making this information freely available online will help researchers to navigate the complex and changing environment of the brain in Alzheimer’s and identify processes that could be targeted by future drugs.”
“There are over half a million people in the UK living with Alzheimer’s and there are currently no treatments that can slow or stop the disease from progressing in the brain. Pioneering research like this is driving progress towards new breakthroughs that will change people’s lives.”